Jake Gyllenhaal and Anne Hathaway, who played a doomed husband and wife in “Brokeback Mountain,” are in negotiations to reunite for “Love and Other Drugs.”

Ed Zwick  is directing the Fox 2000/New Regency project (formerly titled “Pharma”), which Charles Randolph  adapted from Jamie Reidy’s non-fiction book “Hard Sell: The Evolution of a Viagra Salesman.”

Reidy was a drug rep for Pfizer in the late 1990s whose memoir shone a light on the practices of the pharmaceutical industry. Gyllenhaal will play the salesman, who begins a relationship with a woman who has Parkinson’s disease (Hathaway) while on one of his sales calls. Their love story plays out in the political and social context of the time.

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